ژورنال اصلی BioMed Central Ltd.

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گت بلاگز Internet Genetic and epigenetic studies of atopic dermatitis / دانلود فایل

مشخصات کلی Genetic and epigenetic studies of atopic dermatitis

نویسنده کتاب (Author):

Bin, Lianghua; Leung, Donald

انتشارات (Publisher):

BioMed Central Ltd. 2016-10-19

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Atopic dermatitis, Genetics, Epigenetic, Innate immunity, Adaptive immunity, Skin barrier, Genetic association, miRNA, DNA methylation      

توضیحات خلاصه (Summary):

Abstract Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex interaction of genetic, immune and environmental factors. There have many recent discoveries involving the genetic and epigenetic studies of AD. Methods A retrospective PubMed search was carried out from June 2009 to June 2016 using the terms “atopic dermatitis”, “association”, “eczema”, “gene”, “polymorphism”, “mutation”, “variant”, “genome wide association study”, “microarray” “gene profiling”, “RNA sequencing”, “epigenetics” and “microRNA”. A total of 132 publications in English were identified. Results To elucidate the genetic factors for AD pathogenesis, candidate gene association studies, genome-wide association studies (GWAS) and transcriptomic profiling assays have been performed in this period. Epigenetic mechanisms for AD development, including genomic DNA modification and microRNA posttranscriptional regulation, have been explored. To date, candidate gene association studies indicate that filaggrin ( FLG ) null gene mutations are the most significant known risk factor for AD, and genes in the type 2 T helper lymphocyte (Th2) signaling pathways are the second replicated genetic risk factor for AD. GWAS studies identified 34 risk loci for AD, these loci also suggest that genes in immune responses and epidermal skin barrier functions are associated with AD. Additionally, gene profiling assays demonstrated AD is associated with decreased gene expression of epidermal differentiation complex genes and elevated Th2 and Th17 genes. Hypomethylation of TSLP and FCER1G in AD were reported; and miR-155, which target the immune suppressor CTLA – 4 , was found to be significantly over-expressed in infiltrating T cells in AD skin lesions. Conclusions The results suggest that two major biologic pathways are responsible for AD etiology: skin epithelial function and innate/adaptive immune responses. The dysfunctional epidermal barrier and immune responses reciprocally affect  Read more…

ژانر / فرم:Review

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Bin, Lianghua; Leung, Donald

شناسه OCLC:979265200

Language Note:English

نویسنده : getblogs