Genetic and epigenetic studies of atopic dermatitis / دانلود فایل

مشخصات کلی Genetic and epigenetic studies of atopic dermatitis

نویسنده کتاب (Author):

Bin, Lianghua; Leung, Donald

انتشارات (Publisher):

BioMed Central Ltd. 2016-10-19

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Atopic dermatitis, Genetics, Epigenetic, Innate immunity, Adaptive immunity, Skin barrier, Genetic association, miRNA, DNA methylation      

توضیحات خلاصه (Summary):

Abstract Background Atopic dermatitis (AD) is a chronic inflammatory disease caused by the complex interaction of genetic, immune and environmental factors. There have many recent discoveries involving the genetic and epigenetic studies of AD. Methods A retrospective PubMed search was carried out from June 2009 to June 2016 using the terms “atopic dermatitis”, “association”, “eczema”, “gene”, “polymorphism”, “mutation”, “variant”, “genome wide association study”, “microarray” “gene profiling”, “RNA sequencing”, “epigenetics” and “microRNA”. A total of 132 publications in English were identified. Results To elucidate the genetic factors for AD pathogenesis, candidate gene association studies, genome-wide association studies (GWAS) and transcriptomic profiling assays have been performed in this period. Epigenetic mechanisms for AD development, including genomic DNA modification and microRNA posttranscriptional regulation, have been explored. To date, candidate gene association studies indicate that filaggrin ( FLG ) null gene mutations are the most significant known risk factor for AD, and genes in the type 2 T helper lymphocyte (Th2) signaling pathways are the second replicated genetic risk factor for AD. GWAS studies identified 34 risk loci for AD, these loci also suggest that genes in immune responses and epidermal skin barrier functions are associated with AD. Additionally, gene profiling assays demonstrated AD is associated with decreased gene expression of epidermal differentiation complex genes and elevated Th2 and Th17 genes. Hypomethylation of TSLP and FCER1G in AD were reported; and miR-155, which target the immune suppressor CTLA – 4 , was found to be significantly over-expressed in infiltrating T cells in AD skin lesions. Conclusions The results suggest that two major biologic pathways are responsible for AD etiology: skin epithelial function and innate/adaptive immune responses. The dysfunctional epidermal barrier and immune responses reciprocally affect  Read more…

ژانر / فرم:Review

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Bin, Lianghua; Leung, Donald

شناسه OCLC:979265200

Language Note:English

Potential factors involved in the causation of rhabdomyolysis following status asthmaticus / دانلود فایل

مشخصات کلی Potential factors involved in the causation of rhabdomyolysis following status asthmaticus

نویسنده کتاب (Author):

Qiao, Hongmei; Cheng, Huanji; Liu, Li; Yin, Jianing

انتشارات (Publisher):

BioMed Central Ltd. 2016-08-22

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Rhabdomyolysis, Status asthmaticus, Risk factors, Respiratory muscle exertion, Medication, Mechanical ventilation      

توضیحات خلاصه (Summary):

Abstract Rhabdomyolysis is a rare but potentially fatal complication of status asthmaticus. Since the first case was reported in 1978, only a few dozen cases have been described till date. We performed a literature review with the aim to characterize the pathophysiological basis of the occurrence of rhabdomyolysis in patients with status asthmaticus. Excessive exertion of respiratory muscles, hypoxia and acidosis, electrolyte imbalance, infections, some drugs used for asthma control, use of mechanical ventilation, prolonged cardiopulmonary resuscitation, higher age of the patient and some underlying diseases or genetic factors appear to be involved in its causation. In patients with status asthmaticus, it is important to pay more attention to these factors and to closely monitor creatine kinase levels in blood so as to ensure early detection of rhabdomyolysis.  Read more…

ژانر / فرم:Review

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Qiao, Hongmei; Cheng, Huanji; Liu, Li; Yin, Jianing

شناسه OCLC:979265188

Language Note:English

A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin / دانلود فایل

مشخصات کلی A role for auto-immunity in chronic rhinosinusitis? Lessons learned from sub-epidermal bullous disorders of the skin

نویسنده کتاب (Author):

Lefrançois, Philippe; Chapdelaine, Hugo; Côté, Benoît; Desrosiers, Martin

انتشارات (Publisher):

BioMed Central Ltd. 2016-08-05

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Chronic rhinosinusitis, Auto-immunity, IgE, Blistering skin disorders, Bullous pemphigoid      

توضیحات خلاصه (Summary):

Abstract Chronic rhinosinusitis (CRS) is a frequent chronic condition, which has origins in complex interactions between genetic, immunological and microbial factors. The role of auto-immunity in CRS remains unclear, although recent studies have started to emerge in CRS patient refractory to maximal medical management. We discuss the possible auto-immunity link between CRS and other skin diseases, in particular acquired bullous dermatoses, and review the current evidence. We raise additional considerations for auto-immunity from both research and clinical standpoints.  Read more…

ژانر / فرم:Review

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Lefrançois, Philippe; Chapdelaine, Hugo; Côté, Benoît; Desrosiers, Martin

شناسه OCLC:979265170

Language Note:English

Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence / دانلود فایل

مشخصات کلی Patient engagement and patient support programs in allergy immunotherapy: a call to action for improving long-term adherence

نویسنده کتاب (Author):

Demoly, Pascal; Passalacqua, Giovanni; Pfaar, Oliver; Sastre, Joaquin; Wahn, Ulrich

انتشارات (Publisher):

BioMed Central Ltd. 2016-07-29

ویرایش و نوع فایل (Edition/Format):

 Downloadable article : English

منبع (Database):

WorldCat

عنوان ژورنال (Publication):

BioMed Central Ltd.

موضوع (Subject):

Adherence, Patient engagement, Patient support program, Allergy immunotherapy      

توضیحات خلاصه (Summary):

Abstract Allergy immunotherapy (AIT) is acknowledged to produce beneficial mid- and long-term clinical and immunologic effects and increased quality of life in patients with allergic respiratory diseases (such as allergic rhinoconjunctivitis and allergic asthma). However, poor adherence to AIT (due to intentional and/or non-intentional factors) is still a barrier to achieving these benefits. There is an urgent need for patient support programs (PSPs) that encompass communication, educational and motivational components. In the field of AIT, a PSP should be capable of (1) improving adherence, (2) boosting patient engagement, (3) explaining how AIT differs from pharmacological allergy treatments; (4) increasing health literacy about chronic, progressive, immunoglobulin-E-mediated immune diseases, (5) helping the patient to understand and manage local or systemic adverse events, and (6) providing and/or predicting local data on aeroallergen levels. We reviewed the literature in this field and have identified a number of practical issues to be addressed when implementing a PSP for AIT: the measurement of adherence, the choice of technologies, reminders, communication channels and content, the use of “push” messaging and social networks, interactivity, and the involvement of caregivers and patient leaders. A key issue is “hi-tech” (i.e. approaches based mainly on information technology) vs. “hi-touch” (based mainly on interaction with humans, i.e. family members, patient mentors and healthcare professionals). We conclude that multistakeholder PSPs (combining patient-, provider and society-based actions) must now be developed and tested with a view to increasing adherence, efficacy and safety in the field of AIT.  Read more…

ژانر / فرم:Review

موضوع:Internet resource

نوع منبع:Internet Resource, Article

تمام نویسندگان / همکاران: Demoly, Pascal; Passalacqua, Giovanni; Pfaar, Oliver; Sastre, Joaquin; Wahn, Ulrich

شناسه OCLC:979265168

Language Note:English